Key result
Higher hsCRP was only weakly associated with higher pulse wave velocity (beta=0.06, P<0.05) and more atherosclerotic plaques (beta=0.04, P=0.06) after adjusting for traditional CV risk factors.
Why the study?
Is high-sensitivity C-reactive protein associated with subclinical cardiovascular damage independently of traditional cardiovascular risk factors in apparently healthy individuals?
Population
2028 apparently healthy individuals without prior stroke or myocardial infarction not receiving any CV…
Design
Cross-sectional
Authors
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hsCRP adds little independently to traditional factors for subclinical damage; leaves open its incremental value in early atherosclerosis assessment.
Cross-Sectional (n=2,028)
Is high-sensitivity C-reactive protein associated with subclinical cardiovascular damage independently of traditional cardiovascular risk factors in apparently healthy individuals?
Effect estimate: beta 0.06
p-value: p=<0.05
hsCRP is only weakly associated with subclinical cardiovascular damage after adjusting for traditional risk factors, suggesting it acts more as an integrated marker of early atherosclerosis rather than an independent driver.
Olsen et al. (2006) conducted a cross-sectional in Healthy individuals (n=2,028). High-sensitivity C-reactive protein (hsCRP) was evaluated on Subclinical cardiovascular damage (pulse wave velocity and atherosclerotic plaques) (beta 0.06, p=<0.05). Higher hsCRP was only weakly associated with higher pulse wave velocity (beta=0.06, P<0.05) and more atherosclerotic plaques (beta=0.04, P=0.06) after adjusting for traditional CV risk factors.
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