Why the study?
Does dofetilide reduce heart rate in midgestation rat embryos in vitro?
Population
Gestation day 11 (GD11) and 14 (GD14) rat embryos in vitro
Design
Preclinical
Follow-up
up to 4 hours
Authors
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Suggests bradycardia-driven hypoxia as mechanism of dofetilide embryotoxicity in rats; hypothesis-generating and leaves open human relevance.
Does dofetilide reduce heart rate in midgestation rat embryos in vitro?
Dofetilide causes dose-dependent bradycardia in rat embryos in vitro, suggesting that the embryotoxicity of Class III antiarrhythmics may be driven by embryonic heart rate reduction and subsequent hypoxia.
Spence et al. (1994) studied this question.
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