Why the study?
Does TA-6366 improve morphological changes and mechanical properties related to sodium ion permeability in the aorta of spontaneously hypertensive rats compared to enalapril and captopril?
Population
Spontaneously hypertensive rats (SHRs) from 4 weeks of age
Comparison
TA-6366 administered orally for 10 weeks vs Enalapril and captopril (5 mg/kg/d)
Design
Preclinical
Follow-up
10 weeks
Authors
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TA-6366 merits further preclinical study for vascular protection; leaves open any clinical advantage over ACE inhibitors.
Does TA-6366 improve morphological changes and mechanical properties related to sodium ion permeability in the aorta of spontaneously hypertensive rats compared to enalapril and captopril?
TA-6366 demonstrates more prominent preventive effects against progression of vascular diseases accompanied with hypertension in SHRs compared to enalapril and captopril.
Kubo et al. (1992) studied this question.
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