January 22, 2015Frontiers in Public HealthOpen Access

The Association between Antidepressant Medications and Coronary Heart Disease in Brazil: A Cross-Sectional Analysis on the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil)

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Why the study?

Does antidepressant use (specifically tricyclic antidepressants) increase the prevalence of coronary heart disease in Brazilian adults?

Population

14,994 civil servants aged 35-74 years from the baseline assessment of the Brazilian Longitudinal Study of…

Comparison

Antidepressant use, including selective… vs Non-use of antidepressants.

Design

Cross-sectional

Authors

AKAndrew H. KempNorthwestern University ABAndré R. BrunoniThe University of Texas Southwestern Medical Center MBMárcio Sommer BittencourtCardiac Imaging

Discussion

Member takes

Implication

TCA-CHD link in Brazilian adults should not yet change practice; leaves open causality and needs longitudinal confirmation.

Structured PICO

Does antidepressant use (specifically tricyclic antidepressants) increase the prevalence of coronary heart disease in Brazilian adults?

Population

14,994 civil servants aged 35-74 years from the baseline assessment of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Intervention

Antidepressant use (taking at least one antidepressant medicine continuously in the past 2 weeks), including selective serotonin reuptake inhibitors (SSRI), serotonin and noradrenaline reuptake inhibitors (SNRI), tricyclic antidepressants (TCA), and other antidepressants.

Comparator

Non-use of antidepressants.

Outcome

Prevalent coronary heart disease (CHD), defined as a prior history of physician-diagnosed myocardial infarction, prior percutaneous coronary intervention, prior surgical revascularization, or history of stable angina.hard clinical

Tricyclic antidepressant use is strongly associated with prevalent coronary heart disease, specifically myocardial infarction and revascularization, highlighting the potential risks of their unrestricted use in public health systems.

Limitations

Cross-sectional design precludes any conclusions over the causal relationship between TCA use and CHD
Some participants may have been using low-dose TCAs to treat conditions other than mental disorders, such as chronic/neuropathic pain and sleep issues

Cite This Study

Kemp et al. (2015) studied this question.

synapsesocial.com/papers/6a227f80ffccceb004b73115 https://doi.org/10.3389/fpubh.2015.00009

View Full Paper

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The Association between Antidepressant Medications and Coronary Heart Disease in Brazil: A Cross-Sectional Analysis on the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil)

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The Association between Antidepressant Medications and Coronary Heart Disease in Brazil: A Cross-Sectional Analysis on the Brazilian Longitudinal Study of Adult Health (ELSA-Brazil)

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider