Key result
Citalopram treatment resulted in a small reduction in heart rate (≤8 beats per minute) but had no significant effects on PQ, QRS, or QTc intervals.
Why the study?
Does citalopram affect cardiac conduction and repolarization in healthy volunteers and patients with depression or dementia?
Does citalopram affect cardiac conduction and repolarization in healthy volunteers and patients with depression or dementia?
Citalopram appears to have a benign cardiovascular safety profile with no significant adverse effects on cardiac conduction or repolarization.
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Supports citalopram's benign conduction profile; leaves open arrhythmia risk in high-risk cardiac populations.
Rasmussen et al. (1999) conducted a review in Major depression and/or dementia (n=3,272). Citalopram vs. Placebo or active control was evaluated on ECG parameters (PQ, QRS, QTc intervals and heart rate). Citalopram treatment resulted in a small reduction in heart rate (≤8 beats per minute) but had no significant effects on PQ, QRS, or QTc intervals.
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