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February 1, 1994Circulation Research

Enhanced Na(+)-Ca2+ exchange activity in cardiomyopathic Syrian hamster.

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Population

Cardiomyopathic Syrian hamsters in the late stage of cardiomyopathy and age-matched healthy hamsters

Comparison

Measurement of membrane current, cell… vs Age-matched healthy hamster hearts

Design

Preclinical

Authors

SHStéphane HatemElectrophysiologyJSJames S.K. ShamJohns Hopkins UniversityMMMartin MoradElectrophysiology

Discussion

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Implication

Altered Ca currents in myopathic hamster myocytes should not change practice; leaves open mechanistic roles in human cardiomyopathy.

Structured PICO

P
Population
Cardiomyopathic Syrian hamsters (BIO 14.6) in the late stage of cardiomyopathy (220 to 300 days old) and age-matched healthy hamsters
I
Intervention
Measurement of membrane current, cell shortening, and intracellular Ca2+ transients in isolated whole-cell-clamped myocytes
C
Comparator
Age-matched healthy hamster hearts
O
Outcome
L-type Ca2+ current density, Na(+)-Ca2+ exchanger current (INa-Ca), contraction, and intracellular Ca2+ transientssurrogate

Enhanced Na(+)-Ca2+ exchanger activity in cardiomyopathic Syrian hamsters may be related to compromised Ca2+ sequestration, contributing to prolonged contraction and delayed relaxation.

Cite This Study

Hatem et al. (1994) studied this question.

synapsesocial.com/papers/6a227fe8ffccceb004b73243https://doi.org/10.1161/01.res.74.2.253

Topics

Cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Calcium current in congestive heart failure of hamster cardiomyopathy1991 · 36 citations
  2. 2Electrophysiological study of Syrian hamster hereditary cardiomyopathy1978 · 43 citations
  3. 3Alterations in calcium antagonist receptors and sodium-calcium exchange in cardiomyopathic hamster tissues.1989 · 64 citations
  4. 4Inotropic and calcium kinetic effects of calcium channel agonist and antagonist in isolated cardiac myocytes from cardiomyopathic hamsters.1990 · 46 citations
  5. 5Diminished tolerance of prehypertrophic, cardiomyopathic Syrian hamster hearts to Ca2+ stresses.1991 · 21 citations