Key result
In single rabbit Purkinje cells, [Ca2+]i transients are due to Ca2+-induced Ca2+ release from the SR and activate a Cl- current that does not require membrane depolarization.
Population
Single Purkinje cells enzymatically isolated from rabbit ventricle
Comparison
Whole-cell voltage clamp with internal perfusion… vs Control conditions without pharmacological…
Design
Preclinical
Authors
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No immediate clinical implications; leaves open the role of ICl(Ca) in human Purkinje arrhythmogenesis.
Identifies and characterizes a calcium-activated chloride current in rabbit ventricular Purkinje cells driven by sarcoplasmic reticulum calcium release.
SIPIDO et al. (1993) studied this question. Voltage clamp and pharmacological agents was evaluated on [Ca2+]i transients and [Ca2+]i-dependent chloride current. In single rabbit Purkinje cells, [Ca2+]i transients are due to Ca2+-induced Ca2+ release from the SR and activate a Cl- current that does not require membrane depolarization.
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