Key result
Abdominal aortic coarctation in guinea pigs prolonged action potential duration at 90% repolarisation in left ventricular myocytes compared to controls (358 vs 310 ms; p<0.05).
Population
Immature female guinea pigs
Comparison
Abdominal aortic coarctation fashioned… vs Control group
Design
Preclinical
Follow-up
20 weeks
Authors
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Hypothesis-generating for hypertrophy-related arrhythmogenesis in guinea pigs; leaves open translation to human ventricular remodeling.
Absolute Event Rate: 358% vs 310%
p-value: p=< 0.05
Abdominal aortic coarctation in guinea pigs leads to prolonged action potential duration in left ventricular myocytes, driven by increased calcium current density and altered sodium-calcium exchange, which are potentially arrhythmogenic.
Ryder et al. (1993) studied Abdominal aortic coarctation. Abdominal aortic coarctation vs. Control was evaluated on Action potential duration at 90% repolarisation (p=< 0.05). Abdominal aortic coarctation in guinea pigs prolonged action potential duration at 90% repolarisation in left ventricular myocytes compared to controls (358 vs 310 ms; p<0.05).
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