Why the study?
Does pressure-overload left ventricular hypertrophy alter cell shortening and contraction kinetics in response to depolarization in guinea-pig left ventricular myocytes?
Population
Single left ventricular myocytes from guinea-pigs with mild pressure-overload left ventricular hypertrophy…
Comparison
Step depolarizations from a holding potential of… vs Myocytes from sham-operated guinea-pigs
Design
Preclinical
Authors
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May indicate enhanced calcium handling in hypertrophied myocytes; hypothesis-generating for human pressure-overload LVH.
Does pressure-overload left ventricular hypertrophy alter cell shortening and contraction kinetics in response to depolarization in guinea-pig left ventricular myocytes?
Pressure-overload left ventricular hypertrophy in guinea-pigs is associated with increased cell shortening and altered contraction kinetics in isolated myocytes, suggesting increased calcium entry via sodium-calcium exchange.
Ryder et al. (1993) studied this question.
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