Key result
Voltage-clamp depolarizations in guinea pig ventricular myocytes demonstrated that slow inward current induces and grades the size of calcium release from the sarcoplasmic reticulum.
Population
Single voltage-clamped, internally perfused myocytes isolated from guinea pig ventricles
Comparison
Voltage-clamp depolarizations vs Different voltage steps or baseline conditions
Design
Preclinical
Authors
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No immediate clinical implications; leaves open translation of voltage-dependent SR Ca release to human myocytes and HF models.
The study provides direct evidence that the slow inward calcium current both induces and grades the size of calcium release from the sarcoplasmic reticulum in intact cardiac muscle.
London et al. (1986) studied this question. Voltage-clamp depolarizations was evaluated on Contraction and sarcomere shortening. Voltage-clamp depolarizations in guinea pig ventricular myocytes demonstrated that slow inward current induces and grades the size of calcium release from the sarcoplasmic reticulum.
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