What does this research mean for the field?

Voltage-dependent and sodium-dependent Na+-Ca2+ exchange during the diastolic interval regulates resting intracellular calcium levels, which determines sarcoplasmic reticulum calcium accumulation and subsequent contraction magnitude in cardiac myocytes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1991British Journal of PharmacologyOpen Access

The control of the contraction of myocytes from guinea‐pig heart by the resting membrane potential

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Population

Enzymatically dispersed myocytes from guinea-pig hearts

Comparison

Different holding potentials with varying Na+… vs Standard Na+ gradients

Design

Preclinical

Authors

JMJ. MermiKlinikum Dortmund MYMichio YajimaAichi Medical University FEF. EbnerEssen University Hospital

Discussion

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Implication

Highlights diastolic NCX role in myocyte Ca2+ and contractility; leaves open translation to human HF or arrhythmias.

Structured PICO

Population

Enzymatically dispersed myocytes from guinea-pig hearts

Intervention

Different holding potentials (-120 to -70 mV) with varying Na+ gradients or Na+-pump inhibition with ouabain 1-10 mumol l-1

Comparator

Standard Na+ gradients (140 mmol l-1 [Na+]o and 5 mmol l-1 pipette Na+)

Outcome

Myocyte shortening and holding currentsurrogate

In guinea-pig ventricular myocytes, voltage- and Na+-dependent Na+-Ca2+ exchange during diastole regulates intracellular Ca2+ accumulation and subsequent contraction strength.

Cite This Study

Mermi et al. (1991) studied this question.

synapsesocial.com/papers/6a1ebc8f6b4935698da443a8 https://doi.org/10.1111/j.1476-5381.1991.tb12492.x

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The control of the contraction of myocytes from guinea‐pig heart by the resting membrane potential

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The control of the contraction of myocytes from guinea‐pig heart by the resting membrane potential

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider