Population
Isolated guinea-pig ventricular myocytes
Comparison
Pharmacological agents and voltage clamp protocols vs Control conditions
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for a distinct voltage-dependent SR Ca2+ trigger in cardiac myocytes.
This study identifies a distinct voltage-dependent trigger mechanism for sarcoplasmic reticulum calcium release in cardiac myocytes that is independent of Na+ and L-type Ca2+ currents.
Ferrier et al. (1995) studied this question.
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