Inward current related to contraction in guinea‐pig ventricular myocytes.
Population
Isolated guinea-pig ventricular cells
Comparison
Electrophysiological stimulation and… vs Control conditions
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
No immediate clinical implications; leaves open the current's role in human calcium handling and arrhythmias.
Structured PICO
P
Population
Isolated guinea-pig ventricular cells
I
Intervention
Electrophysiological stimulation and pharmacological manipulation (adrenaline, EGTA, strontium, ryanodine)
C
Comparator
Control conditions
O
Outcome
Amplitude, kinetics, and voltage dependence of the delayed inward current and its correlation with cell contractionsurrogate
Demonstrates that a delayed inward current in ventricular myocytes is closely tied to the intracellular calcium transient and cell contraction, likely mediated by sodium-calcium exchange.
Cite This Study
Fedida et al. (1987) studied this question.