Population
Single cells isolated from guinea-pig ventricular muscle
Comparison
Voltage clamp depolarizations at +60 mV with… vs Depolarizations at 0 mV
Design
Preclinical
Authors
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Hypothesis-generating for non-L-type calcium entry in myocytes; does not yet inform clinical calcium channel blocker use.
Calcium entry at positive membrane potentials in guinea-pig ventricular cells occurs through voltage-dependent, non-inactivating pathways that are insensitive to nifedipine but inhibited by dodecylamine, potentially contributing to intracellular calcium store loading.
Terrar et al. (1989) studied this question.
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