Population
Single ventricular muscle cells isolated from rat and guinea-pig hearts
Comparison
Electrophysiological interventions and… vs Comparison between rat and guinea-pig…
Design
Preclinical
Authors
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Species differences in calcium sources for contraction require model-specific interpretation; extends EC coupling knowledge but leaves open human translation.
This preclinical study highlights fundamental species differences in excitation-contraction coupling, showing rat ventricular cells depend primarily on sarcoplasmic reticulum calcium release while guinea-pig cells depend more on trans-sarcolemmal calcium influx.
Mitchell et al. (1987) studied this question.
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