Population
Single cells isolated from rat and guinea-pig ventricular muscle
Design
Preclinical
Authors
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Species differences in ryanodine effects caution against rodent model extrapolation; leaves open translational relevance of calcium-activated currents to human hearts.
An inward current activated by internal calcium contributes to the late phase of the action potential in rat cells and the plateau in guinea-pig cells, with the rat mechanism largely dependent on ryanodine-sensitive calcium release.
Mitchell et al. (1984) studied this question.
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