Population
Single voltage-clamped guinea pig ventricular myocytes
Comparison
Ryanodine 10 microM vs Cells without internal EGTA vs cells perfused…
Design
Preclinical
Authors
Loading...
Ryanodine effects on ICa require intracellular Ca2+; leaves open direct L-type–ryanodine receptor coupling in intact myocytes.
The effects of ryanodine on calcium current in guinea pig ventricular myocytes are mediated by intracellular calcium rather than a direct physical connection between L-type calcium channels and ryanodine receptors.
Balke et al. (1991) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: