May 1, 1986Circulation Research

Ryanodine inhibits the release of calcium from intracellular stores in guinea pig aortic smooth muscle.

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Population

Guinea pig aortic smooth muscle

Design

Preclinical

Authors

KIKatsuaki ItoUniversity of North Carolina at Chapel Hill STSachiko TakakuraUniversity of Miyazaki KSKoichi SatoYamaguchi University

Discussion

Member takes

Implication

Suggests intracellular Ca2+ release contributes to vascular contraction; hypothesis-generating in animals and should not change practice.

Structured PICO

Population

Guinea pig aortic smooth muscle

Intervention

Ryanodine (3-100 microM)

Outcome

Contractile tension and calcium-45 movementsurrogate

Ryanodine inhibits calcium release from intracellular stores in vascular smooth muscle, indicating a potential calcium-induced calcium release mechanism in this tissue.

Cite This Study

Ito et al. (1986) studied this question.

synapsesocial.com/papers/6a747745d93df8ecca090e1a https://doi.org/10.1161/01.res.58.5.730

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Ask AI

Bookmark

Ryanodine inhibits the release of calcium from intracellular stores in guinea pig aortic smooth muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ryanodine inhibits the release of calcium from intracellular stores in guinea pig aortic smooth muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider