Population
Dispersed smooth muscle cells of rabbit ileal longitudinal layer (Albino rabbits, Nippon White; 1.8-2.2kg)
Comparison
Ryanodine (3-30 microM) vs Baseline/control conditions without ryanodine
Design
Preclinical
Authors
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Should not alter clinical practice; leaves open mechanistic exploration of Ca-dependent currents in smooth muscle.
Ryanodine irreversibly opens Ca channels in intracellular stores, depleting stored Ca and subsequently inhibiting Ca-dependent K channels in rabbit ileal smooth muscle cells.
Sakai et al. (1988) studied this question.
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