Population
Canine ventricular trabeculae
Comparison
Voltage clamp experiments with variable extra… vs Baseline or control conditions
Design
Preclinical
Authors
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Supports Na+-Ca2+ exchange as basis for contraction-related current in canine myocytes; leaves open relevance to human electrophysiology and arrhythmias.
The contraction-related slow inward current in canine ventricular muscle is directly related to contraction amplitude and conforms to a model of electrogenic Na+-Ca2+ exchange activated by intracellular calcium release.
Šimurda et al. (1992) studied this question.
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