Population
Feline ventricular myocytes
Comparison
Voltage-clamp techniques varying membrane… vs Different membrane potentials and pulse durations
Design
Preclinical
Authors
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Distinguishes trigger from loading roles in SR Ca2+ handling; hypothesis-generating in animal myocytes but leaves open in vivo and human translation.
The early peak of the slow inward Ca2+ current acts as a trigger for sarcoplasmic reticulum Ca2+ release, while sarcoplasmic reticulum Ca2+ loading depends on prolonged depolarization, likely mediated by Na+-Ca2+ exchange.
duBell et al. (1989) studied this question.
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