Population
Rabbit sino-atrial (s.a.) node preparations (small, spontaneously beating)
Design
Preclinical
Authors
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May inform SAN current modeling in simulations; leaves open translation to human pacemaker physiology.
The slow inward current in the rabbit sino-atrial node consists of a fast gated calcium current and a slower sodium-calcium exchange current, which can be accurately modeled using computer simulations.
Brown et al. (1984) studied this question.
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