Population
Guinea-pig sinoatrial (SA) node pacemaker cells
Design
Preclinical
Authors
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Ist may contribute to SAN diastolic depolarization in rodents; leaves open its role in human pacemaker function.
The study identifies and characterizes a novel nicardipine-sensitive, Na+-mediated single channel current (ist) that may be responsible for the whole-cell sustained inward current during slow diastolic depolarization in sinoatrial node cells.
Mitsuiye et al. (1999) studied this question.
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