Population
Guinea-pigs; single myocytes isolated from basal sub-endocardial, basal mid-myocardial and apical…
Comparison
Mild cardiac hypertrophy induced by aortic… vs Control hearts
Design
Preclinical
Authors
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May promote re-entry in hypertrophied hearts; hypothesis-generating for human arrhythmia substrates.
Mild left ventricular hypertrophy in guinea pigs alters regional electrical properties, eliminating the normal transmural gradient in action potential duration, which may favor the propagation of re-entry arrhythmias.
Simon M. Bryant (1997) studied this question.
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