Key result
Action potential duration and cell shortening amplitude varied significantly across 20 ventricular regions in normal guinea-pig hearts, correlating with depolarization sequence and wall stress.
Authors
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Regional myocyte data from guinea pigs warrant no clinical change; leaves open human translation and arrhythmia relevance.
Wan et al. (2003) studied Normal guinea-pig ventricular muscle. Topographical region (e.g., subendocardial vs subepicardial, septum vs free wall) vs. Other ventricular regions was evaluated on Electrical and mechanical properties (cell capacitance, APD90, cell length, evoked shortening). Action potential duration and cell shortening amplitude varied significantly across 20 ventricular regions in normal guinea-pig hearts, correlating with depolarization sequence and wall stress.
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