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March 1, 2000Cardiovascular ResearchOpen Access

M cells and transmural heterogeneity of action potential configuration in myocytes from the left ventricular wall of the pig heart

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Population

Single myocytes enzymatically isolated from the epicardium, midmyocardium, and endocardium of the free left…

Design

Preclinical

Authors

TSTania StankovičováComenius University Bratislava

Discussion

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Implication

Supports arrhythmogenesis research in porcine xenotransplant models; hypothesis-generating and requires human validation.

Structured PICO

P
Population
Single myocytes enzymatically isolated from the epicardium (n=29), midmyocardium (n=38), and endocardium (n=13) of the free left ventricular wall of 26 pigs (14-22 weeks old, 55-80 kg).
I
Intervention
Stimulation at different rates (0.25 Hz vs. 2 Hz) during whole-cell recording.
O
Outcome
Action potential duration (APD) and configuration (spike-and-dome, phase 1 magnitude, plateau voltage)surrogate

In young adult pigs, M cells with a steep frequency response and spike-and-dome configuration are present predominantly in the midmyocardium, which is relevant for understanding arrhythmogenesis in pig models used for xenotransplantation.

Cite This Study

Tania Stankovičová (2000) studied this question.

synapsesocial.com/papers/6a714bd3febe604dd709fd13https://doi.org/10.1016/s0008-6363(99)00418-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle. The M cell.1991 · 502 citations
  2. 2Heterogeneity of action potential waveforms and potassium currents in rat ventricle1993 · 231 citations
  3. 3Regional differences in IK density in canine left ventricle: role of IK,s in electrical heterogeneity1995 · 53 citations
  4. 4A Review of Early Intervention Studies with Beta Blockers in Patients with Myocardial Infarction1986 · 22 citations
  5. 5Mechanism of Impaired Myocardial Function During Progressive Coronary Stenosis in Conscious Pigs1995 · 227 citations