Key result
Transmural electrophysiologic differences in K+ currents may explain J and U waves.
The distinct electrophysiologic properties of different ventricular myocardial cell layers provide a cellular basis for electrocardiographic features like the J wave and U wave.
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Cellular basis for J/U waves on ECG; leaves open validation in arrhythmia risk models.
A 1997 study reported a review. Electrophysiologic differences among epicardial, midmyocardial, and endocardial cells, including variations in transient outward and delayed rectifier K+ currents, may explain the J and U waves.
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