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October 15, 1996Circulation

In situ, at all cycle lengths from 300 to 2000 ms, activation-recovery intervals were equal in all myocardial layers from epicardial to endocardial cells.

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Population

Intact normal canine heart and in vitro myocardial cells (epicardial, midmyocardial, and endocardial)

Comparison

Abrupt lengthening of cycle length and in situ… vs Comparison among epicardial, midmyocardial, and…

Design

Preclinical

Authors

EAEvgeny P. AnyukhovskyESEugene A. SosunovMRMichael R. Rosen

Discussion

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Overview

Caution against assuming transmural repolarization gradients in intact hearts; challenges in vitro data and leaves open human in vivo relevance.

Structured PICO

P
Population
Intact normal canine heart and in vitro myocardial cells (epicardial, midmyocardial, and endocardial)
I
Intervention
Abrupt lengthening of cycle length (CL) and in situ AV block with His-bundle pacing
C
Comparator
Comparison among epicardial (Epi), midmyocardial (M), and endocardial (Endo) cells
O
Outcome
Repolarization differences among myocardial layers (action potential duration [APD], activation-recovery intervals [ARIs], and time to steady state [t90])surrogate

In contrast to in vitro findings, there is no significant difference in repolarization among epicardial, midmyocardial, and endocardial layers in the intact normal canine heart.

Cite This Study

Anyukhovsky et al. (1996) studied this question.

synapsesocial.com/papers/6a0883c37de338f10b10bee5https://doi.org/10.1161/01.cir.94.8.1981
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle.1993 · 464 citations
  2. 2Electrophysiology of Myocardial Cells in the Epicardial, Midmyocardial, and Endocardial Layers of the Ventricle1997 · 14 citations
  3. 3Rate-dependent differences in dog epi- and endocardial monophasic action potential configuration in vivo1991 · 22 citations
  4. 4Endocardial versus epicardial differences in L-type calcium current in canine ventricular myocytes studied by action potential voltage clamp2003 · 93 citations
  5. 5Modulation of Transmural Repolarization2005 · 55 citations