October 2, 2001Circulation

Electrical Remodeling in Pressure-Overload Cardiac Hypertrophy

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Population

Mouse hearts subjected to pressure overload by surgical thoracic aortic banding

Comparison

Pressure overload with or without cyclosporin A vs Unbanded control hearts (unoperated conditions)

Design

Preclinical

Authors

ZWZhengyi WangThe University of Western Australia WKWilliam KutschkeUniversity of Iowa KRKenneth E. RichardsonTexas A&M Health Science Center

Discussion

Member takes

Implication

Calcineurin may drive Ca2+ current changes in animal hypertrophy; leaves open human relevance and therapeutic targeting.

Structured PICO

Population

Mouse hearts subjected to pressure overload by surgical thoracic aortic banding

Intervention

Pressure overload (thoracic aortic banding) with or without cyclosporin A (calcineurin inhibition)

Comparator

Unbanded control hearts (unoperated conditions)

Outcome

Action potential duration (APD) and ion current densities (I(to), I(Ca,L))surrogate

Pressure-overload cardiac hypertrophy induces regional variations in electrophysiological responses, specifically upregulating Ca2+ current via calcineurin, which can be uncoupled from structural remodeling.

Cite This Study

Wang et al. (2001) studied this question.

synapsesocial.com/papers/6a8e608a59e755dcaecd6306 https://doi.org/10.1161/hc3901.095766

View Full Paper

Ask AI

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Electrical Remodeling in Pressure-Overload Cardiac Hypertrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrical Remodeling in Pressure-Overload Cardiac Hypertrophy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider