Key result
In isolated guinea-pig myocytes, left ventricular hypertrophy resulted in quicker electrical (50.3 vs 78.4 ms, P<0.03) and mechanical (205 vs 266 ms, P<0.03) restitution time constants.
Population
Isolated left ventricular myocytes from guinea-pigs with mild left ventricular hypertrophy induced by…
Comparison
Electrical stimulation at different frequencies… vs Isolated left ventricular myocytes from control…
Design
Preclinical
Authors
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Caution against clinical extrapolation from guinea-pig myocytes; leaves open whether altered restitution contributes to human arrhythmia risk.
Absolute Event Rate: 50.3% vs 78.4%
p-value: p=< 0.03
In a guinea-pig model of left ventricular hypertrophy, action potential duration is prolonged at low stimulation frequencies, supporting the role of abnormal repolarization in sudden cardiac death at low heart rates.
Davey et al. (2001) studied Left ventricular hypertrophy. Left ventricular hypertrophy vs. Control was evaluated on Electrical restitution time constant (p=< 0.03). In isolated guinea-pig myocytes, left ventricular hypertrophy resulted in quicker electrical (50.3 vs 78.4 ms, P<0.03) and mechanical (205 vs 266 ms, P<0.03) restitution time constants.