Why the study?
Does cardiac hypertrophy cause delayed conduction and altered repolarization during myocardial ischaemia?
Population
Isolated perfused guinea pig hearts obtained 50 and 150 days after aortic constriction, and patients with…
Comparison
Myocardial ischaemia in the setting of cardiac… vs Sham operated control guinea pig hearts and…
Design
Preclinical
Authors
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May heighten ischemia-related arrhythmia risk in LVH; leaves open whether hypertrophy reversal reduces conduction delay.
Does cardiac hypertrophy cause delayed conduction and altered repolarization during myocardial ischaemia?
Severe cardiac hypertrophy is associated with delayed conduction that is further accentuated during ischaemia, providing an electrophysiological basis for increased arrhythmia vulnerability.
Winterton et al. (1994) studied this question.
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