Key result
Stretching single guinea-pig ventricular myocytes by approximately 3% significantly decreased action potential duration (P<0.01) and intracellular calcium transient duration (P<0.025).
Population
Single guinea-pig ventricular myocytes
Comparison
Stretch vs Baseline (before stretch)
Design
Preclinical
Authors
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New single-myocyte setup enables simultaneous length, auxotonic, and Ca²⁺ recordings; leaves open translation to intact-heart mechanics.
p-value: p=<0.01
In single guinea-pig ventricular myocytes, stretching decreases action potential and calcium transient duration without affecting their amplitudes, suggesting time courses are more dependent on tension than length.
White et al. (1993) studied Guinea-pig ventricular myocytes. Stretch (increasing cell length) vs. Baseline/Unstretched was evaluated on Action potential duration and intracellular calcium transient duration (p=<0.01). Stretching single guinea-pig ventricular myocytes by approximately 3% significantly decreased action potential duration (P<0.01) and intracellular calcium transient duration (P<0.025).
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