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March 15, 1996The Journal of PhysiologyOpen Access

Changes in Ca2+i, Na+i and Ca2+ current in isolated rat ventricular myocytes following an increase in cell length.

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Population

Isolated rat ventricular myocytes

Design

Preclinical

Authors

KHKazuhiro HongoEWEd WhiteJGJ.-Y. Le Guennec

Discussion

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Overview

Animal data on stretch-induced inotropy are hypothesis-generating; leaves open translation to intact hearts or clinical settings.

Structured PICO

P
Population
Isolated rat ventricular myocytes
I
Intervention
Mechanical stretch using carbon fibres
O
Outcome
Changes in contraction, intracellular calcium ([Ca2+]i), intracellular sodium ([Na+]i), and L-type Ca2+ currentsurrogate

The study demonstrates that stretch-induced increases in myocardial contraction are mediated by early changes in myofilament calcium sensitivity and late increases in calcium transients, rather than changes in sodium or L-type calcium currents.

Cite This Study

Hongo et al. (1996) studied this question.

synapsesocial.com/papers/6a70a203fe4101aa97e04082https://doi.org/10.1113/jphysiol.1996.sp021243
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stretch‐induced increase of resting intracellular calcium concentration in single guinea‐pig ventricular myocytes1991 · 70 citations
  2. 2The effects of mechanical loading and changes of length on single guinea‐pig ventricular myocytes.1995 · 107 citations
  3. 3Contraction and intracellular Ca2+, Na+, and H+ during acidosis in rat ventricular myocytes1992 · 132 citations
  4. 4Calcium channel currents recorded from isolated myocytes of rat basilar artery are stretch sensitive.1993 · 129 citations
  5. 5Calcium concentration in the myoplasm of skinned ferret ventricular muscle following changes in muscle length.1988 · 137 citations