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July 3, 2004The Journal of PhysiologyOpen Access

Activation of Na+–H+ exchange and stretch‐activated channels underlies the slow inotropic response to stretch in myocytes and muscle from the rat heart

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Population

Single ventricular myocytes and multicellular papillary muscle preparations from the rat heart

Comparison

Myocardial stretch (approximately 7% for… vs Stretch without specific pharmacological…

Design

Preclinical

Authors

SCSarah CalaghanEWEd White

Discussion

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Overview

Does not support clinical translation; leaves open whether NHE/SAC pathways mediate stretch responses in human myocardium.

Structured PICO

P
Population
Single ventricular myocytes and multicellular papillary muscle preparations from the rat heart
I
Intervention
Myocardial stretch (approximately 7% for myocytes, 88 to 98% of L(max) for papillary muscles) with pharmacological inhibition using HOE 642 (NHE inhibitor), LY294002 (PtdIns-3-OH kinase inhibitor), L-NAME (NO synthase inhibitor), ryanodine/thapsigargin (SR inhibitors), or streptomycin (SAC blocker)
C
Comparator
Stretch without specific pharmacological inhibition
O
Outcome
Magnitude of the slow force response and stretch-induced increase in [Ca(2+)](i) transient amplitudesurrogate

In rat heart models, the slow inotropic response to myocardial stretch is mediated by intrinsic myocyte mechanisms involving the activation of Na+-H+ exchange and stretch-activated channels.

Cite This Study

Calaghan et al. (2004) studied this question.

synapsesocial.com/papers/6a739b46f7b0ff0da5850652https://doi.org/10.1113/jphysiol.2004.069021
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stretch-elicited Na+/H+ exchanger activation: the autocrine/paracrine loop and its mechanical counterpart2003 · 34 citations
  2. 2Changes in [Ca2+]i, [Na+]i and Ca2+ current in isolated rat ventricular myocytes following an increase in cell length.1996 · 99 citations
  3. 3Mechanisms Underlying the Increase in Force and Ca <sup>2+</sup> Transient That Follow Stretch of Cardiac Muscle1999 · 203 citations
  4. 4Streptomycin and intracellular calcium modulate the response of single guinea‐pig ventricular myocytes to axial stretch2003 · 82 citations
  5. 5Coronary perfusion and muscle lengthening increase cardiac contraction: different stretch-triggered mechanisms2002 · 29 citations