Population
Isolated right ventricular muscles from adult rabbit hearts (n=81)
Comparison
Rapid stretch from 88% of optimal length to near… vs Pre-stretch values and control conditions…
Design
Preclinical
Authors
Loading...
Requires validation in human myocardium before any clinical inference; extends mechanistic evidence for NHE/NCX dependence of the slow force response in rabbits.
The slow force response to stretch in rabbit myocardium is dependent on Na+ and Ca2+ via activation of NHE and reverse mode NCX, independent of AT1 or ET(A) receptor activation.
VONLEWINSKI et al. (2003) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: