Population
Single guinea-pig ventricular myocytes (n=24 cells tested for current-voltage relationship)
Comparison
Streptomycin or BAPTA-AM during axial stretch vs Unstretched myocytes or stretched myocytes…
Design
Preclinical
Authors
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Hypothesis-generating in isolated myocytes; leaves open whether stretch-activated channels or calcium signaling modulate arrhythmias in intact hearts.
Both stretch-activated channels and intracellular calcium are essential for the electrical response of cardiac myocytes to axial stretch, suggesting inter-dependent mechanisms.
Belus et al. (2003) studied this question.
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