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January 1, 1992The Japanese Journal of PhysiologyOpen Access

Effects of Mechanical Stretch on Membrane Currents of Single Ventricular Myocytes of Guinea-Pig Heart.

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Population

Single ventricular myocytes dissociated from guinea-pig hearts

Comparison

Mechanical stretch vs Hypo-osmotic cell inflation

Design

Preclinical

Authors

NSNorihito SasakiTMTamotsu MitsuiyeANAkinori Noma

Discussion

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Overview

Differentiates stretch- from swelling-induced currents in ventricular myocytes; leaves open their roles in human cardiac electrophysiology.

Structured PICO

P
Population
Single ventricular myocytes dissociated from guinea-pig hearts
I
Intervention
Mechanical stretch (>20% of the length between two fixed points)
C
Comparator
Hypo-osmotic cell inflation (70% hypo-osmotic solution)
O
Outcome
Whole cell membrane current changes (time-independent current)surrogate

Mechanical stretch of guinea-pig ventricular myocytes activates a specific time-independent current distinct from currents induced by hypo-osmotic swelling.

Cite This Study

Sasaki et al. (1992) studied this question.

synapsesocial.com/papers/6a80d900fd865eccc665dcbehttps://doi.org/10.2170/jjphysiol.42.957
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A possible mechanism for large stretch-induced increase in [Ca2+]i in isolated guinea-pig ventricular myocytes1996 · 69 citations
  2. 2The effects of increasing cell length on auxotonic contractions; membrane potential and intracellular calcium transients in single guinea‐pig ventricular myocytes1993 · 116 citations
  3. 3Stretch-activated whole cell currents in adult rat cardiac myocytes2000 · 186 citations
  4. 4Effects of mechanical stretch on the membrane potential of guinea pig ventricular muscles.1988 · 17 citations
  5. 5Streptomycin and intracellular calcium modulate the response of single guinea‐pig ventricular myocytes to axial stretch2003 · 82 citations