Key result
Dopamine and its receptors play a clinically relevant, species-dependent role in mammalian cardiac function, with altered expression and function implicated in conditions such as sepsis.
Why the study?
An update on the role of dopamine receptors in the human heart is clinically relevant to better understand their signaling, expression, and therapeutic potential.
This review summarizes the current understanding of dopamine receptors in the heart, highlighting their species-dependent effects, signal transduction, and potential as therapeutic targets in cardiac diseases.
Warrants caution with dopaminergic agents in sepsis-related cardiac dysfunction; leaves open species-specific therapeutic targeting for future trials.
Dopamine has effects on the mammalian heart. These effects can include an increase in the force of contraction, and an elevation of the beating rate and the constriction of coronary arteries. Depending on the species studied, positive inotropic effects were strong, very modest, or absent, or even negative inotropic effects occurred. We can discern five dopamine receptors. In addition, the signal transduction by dopamine receptors and the regulation of the expression of cardiac dopamine receptors will be of interest to us, because this might be a tempting area of drug development. Dopamine acts in a species-dependent fashion on these cardiac dopamine receptors, but also on cardiac adrenergic receptors. We will discuss the utility of drugs that are currently available as tools to understand cardiac dopamine receptors. The molecule dopamine itself is present in the mammalian heart. Therefore, cardiac dopamine might act as an autocrine or paracrine compound in the mammalian heart. Dopamine itself might cause cardiac diseases. Moreover, the cardiac function of dopamine and the expression of dopamine receptors in the heart can be altered in diseases such as sepsis. Various drugs for cardiac and non-cardiac diseases are currently in the clinic that are, at least in part, agonists or antagonists at dopamine receptors. We define the research needs in order to understand dopamine receptors in the heart better. All in all, an update on the role of dopamine receptors in the human heart appears to be clinically relevant, and is thus presented here.
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Neumann et al. (2023) conducted a review in Cardiac diseases. Dopamine was evaluated. Dopamine and its receptors play a clinically relevant, species-dependent role in mammalian cardiac function, with altered expression and function implicated in conditions such as sepsis.
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