January 1, 2001Japanese Circulation JournalOpen Access

Left Atrial Appendage Dysfunction in Chronic Nonvalvular Atrial Fibrillation is Significantly Associated With an Elevated Level of Brain Natriuretic Peptide and a Prothrombotic State.

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Why the study?

Does left atrial appendage dysfunction correlate with a prothrombotic state and elevated plasma natriuretic peptides in patients with chronic nonvalvular atrial fibrillation?

Population

67 patients with chronic nonvalvular atrial fibrillation of more than 6 months duration, median age 70…

Design

Cross-sectional

Authors

YIYutaka IgarashiGeneral / Preventive / Lipids KKKen KashimuraYokohama City University Medical Center YMYashiro MakiyamaMunicipal Tsuruga Hospital

Discussion

Member takes

Implication

BNP may mark LAA dysfunction in nonvalvular AF; leaves open whether it aids embolism prediction or therapy.

Structured PICO

Does left atrial appendage dysfunction correlate with a prothrombotic state and elevated plasma natriuretic peptides in patients with chronic nonvalvular atrial fibrillation?

Population

67 patients with chronic nonvalvular atrial fibrillation (NVAF) of more than 6 months duration, median age 70 years. Excluded if treated with warfarin prior to transesophageal echocardiography.

Outcome

Correlation between left atrial appendage (LAA) flow velocity and spontaneous echo contrast (SEC) score, left atrial diameter (LAD), D-dimer, brain natriuretic peptide (BNP), and thrombin-antithrombin III complex (TAT)surrogate

In patients with chronic nonvalvular atrial fibrillation, left atrial appendage dysfunction is associated with a prothrombotic state, and elevated plasma BNP may serve as a marker of this dysfunction.

Limitations

Possibility that increased plasma BNP resulted from a secondary decrease in cardiac output caused by left atrial dysfunction
Lack of follow-up to determine whether plasma BNP elevation is related to rapid progression of LAA dysfunction
Exact onset of chronic AF could not be determined in a substantial number of patients

Cite This Study

Igarashi et al. (2001) studied this question.

synapsesocial.com/papers/6a22819d627bd517e16cfd52 https://doi.org/10.1253/jcj.65.788

Topics

Left atrial appendage closure Atrial fibrillation Persistent AF management

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Left Atrial Appendage Dysfunction in Chronic Nonvalvular Atrial Fibrillation is Significantly Associated With an Elevated Level of Brain Natriuretic Peptide and a Prothrombotic State.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Left Atrial Appendage Dysfunction in Chronic Nonvalvular Atrial Fibrillation is Significantly Associated With an Elevated Level of Brain Natriuretic Peptide and a Prothrombotic State.

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider