Human glomerular endothelial cells possess prominent ACE activity but modest ANG II-metabolizing activity compared to podocytes, highlighting distinct roles of glomerular cell types in the intrarenal renin-angiotensin system.
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Distinct glomerular endothelial vs podocyte RAS enzyme profiles may shape local angiotensin signaling; leaves open in vivo relevance for kidney disease.
Velez et al. (2012) studied this question.
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