What question did this study set out to answer?

This research aims to investigate mutations in the RET proto-oncogene and their relation to MEN 2B and sporadic tumors.

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours

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Randomized trial uncovers mutations in RET proto-oncogene linked to MEN 2B and sporadic tumors, suggesting genetic risk factors.

This research aims to investigate mutations in the RET proto-oncogene and their relation to MEN 2B and sporadic tumors.
Analyzed germline DNA from 28 families with MEN 2B for mutations in the RET proto-oncogene.
Examined DNA from sporadic medullary thyroid carcinoma (MTC) and pheochromocytomas for similar mutations.
Found a missense mutation at codon 918 in 26 of 28 MEN 2B families.
Identified similar mutations in five of 13 sporadic MTC cases and one of 12 sporadic pheochromocytomas, with wildtype germline DNA.

Eng et al. (1994) studied this question.

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