Utility of B-type natriuretic peptide for the evaluation of intensive care unit shock*

Roderick Tung; C.M. Castiella García; Alexander M. Morss; Richard M. Pino; Michael A. Fifer; Bruce Thompson; Kent Lewandrowski; Elizabeth Lee-Lewandrowski; James L. Januzzi

doi:10.1097/01.ccm.0000133694.28370.7f

August 1, 2004Critical Care Medicine

Utility of B-type natriuretic peptide for the evaluation of intensive care unit shock*

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Why the study?

Does B-type natriuretic peptide measurement correlate with hemodynamics and predict mortality in critically ill intensive care unit patients with shock?

Key Points

This research investigates the usefulness of B-type natriuretic peptide in evaluating cardiac conditions and mortality risk among ICU patients experiencing shock.
Clinical investigation involving 49 ICU patients with shock requiring pulmonary artery catheterization.
Measured B-type natriuretic peptide levels at catheter placement and correlated them with cardiac metrics and mortality outcomes.
Utilized Spearman analysis and logistic regression for statistical interpretations.
Only 16% of patients had normal B-type natriuretic peptide levels; median levels were significantly higher in non-survivors (943 pg/mL vs. 378 pg/mL, p < .001).
A B-type natriuretic peptide concentration <350 pg/mL had a 95% negative predictive value for cardiogenic shock diagnosis.
The highest log-quartile of B-type natriuretic peptide was a strong mortality predictor (odds ratio = 4.50, 95% CI = 1.87-99.0, p < .001).

Structured PICO

Does B-type natriuretic peptide measurement correlate with hemodynamics and predict mortality in critically ill intensive care unit patients with shock?

P

Population

49 critically ill intensive care unit patients with shock and indication for pulmonary artery catheterization.

I

Intervention

B-type natriuretic peptide (BNP) measurement from blood obtained at the time of pulmonary artery catheter placement.

O

Outcome

Correlation between B-type natriuretic peptide and pulmonary artery occlusion pressure, cardiac index, and mortality.surrogate

In ICU patients with shock, BNP levels do not correlate with pulmonary artery catheter hemodynamics but serve as a strong independent predictor of mortality.

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Implication

BNP should not guide hemodynamic assessment in ICU shock; this observational mortality association leaves open its prognostic role.

Abstract

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Discussion

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Cite This Study

Tung et al. (2004) studied this question.

synapsesocial.com/papers/6a228f24f56da133636d0868 https://doi.org/10.1097/01.ccm.0000133694.28370.7f

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Utility of B-type natriuretic peptide for the evaluation of intensive care unit shock*

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Utility of B-type natriuretic peptide for the evaluation of intensive care unit shock*

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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