Key result
16 weeks of low or moderate-dose moderate-intensity exercise training induced changes in lipoprotein subclass profiles in inactive older women, with no significant differences observed between the two dose groups.
Why the study?
Lipoprotein subclass particles are critical markers of CVD risk, and older women have increased age-related CVD risk, but the effects of low and moderate doses of exercise on these subclasses were undetermined.
Does 16 weeks of low or moderate dose moderate-intensity exercise training improve lipoprotein subclass particle concentrations and sizes in inactive older women?
RCT (n=65)
Open-label
Randomized to one of two moderate-intensity treadmill-walking groups using a list of random numbers, considering age and BMI
No
Does 16 weeks of low or moderate dose moderate-intensity exercise training improve lipoprotein subclass particle concentrations and sizes in inactive older women?
p-value: p=≥0.062
In inactive older women, moderate-intensity exercise at or below the minimally recommended public health dose induces modest but favorable changes in lipoprotein subclasses without significant differences between the two doses studied.
Low-dose exercise alters lipoprotein profiles similarly to moderate doses in older women; extends RCT evidence supporting minimal activity thresholds.
Background: Evidence suggests that lipoprotein subclass particles are critical markers of cardiovascular disease (CVD) risk. Older women have increased CVD risk related to age. The purpose of this study was to determine whether low and moderate doses of exercise influence lipoprotein subclasses. Methods: Women (60–75 years) were randomized into groups for 16 weeks of moderate-intensity exercise training at a low or moderate dose (33.6 and 58.8 kJ/kg body weight weekly, respectively). Lipoprotein subclasses were determined by nuclear magnetic resonance spectroscopy before and after the training. RESULTS: The average weekly exercise duration was 109 and 164 min, for low- and moderate-dose groups, respectively. In the low-dose group, high-density lipoprotein particle (HDL-P) concentration decreased (Δ = −1.9 ± 3.1 µmol/L, mean ± SD, p = 0.002) and mean HDL-P size increased (Δ = 0.1 ± 0.3 nm, p = 0.028). In the moderate-dose group, mean HDL-P size (Δ = 0.1 ± 0.2 nm; p = 0.024) and low-density lipoprotein particle size increased (Δ = 0.4 ± 3.9 nm; p = 0.007). Baseline body mass index, peak oxygen consumption and age were associated with changes in a few lipoprotein subclasses. Conclusions: In this sample of inactive older women, moderate-intensity exercise training at a dose equivalent to or even lower than the minimally recommended level by public health agencies induced changes in lipoprotein subclasses in line with reduced CVD risk. However, higher doses are encouraged for greater health benefits.
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Porter et al. (2023) conducted an RCT in Inactive older women (n=65). Moderate-dose moderate-intensity exercise training vs. Low-dose moderate-intensity exercise training (8 kcal or 33.6 kJ per kg of body weight per week; average 109 min/week) was evaluated on Change in any lipoprotein subclass particle concentration or size (between-group difference) (p=≥0.062). 16 weeks of low or moderate-dose moderate-intensity exercise training induced changes in lipoprotein subclass profiles in inactive older women, with no significant differences observed between the two dose groups.
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