Key result
Targeting regulatory T cells has emerged as a potential therapeutic strategy for cardiovascular diseases by regulating immune balance, suppressing inflammation, and promoting cardiac regeneration.
Why the study?
Targeting regulatory T cells (Tregs) or using them as biomarkers in cardiovascular diseases is an emerging focus, but Tregs exhibit plasticity that may lead to loss of immunosuppressive function and toxic effects.
Targeting regulatory T cells represents an emerging research focus for the prevention and treatment of cardiovascular diseases, though their plasticity remains a challenge.
Should not yet alter cardiovascular disease management; leaves open Treg plasticity and translation challenges for future trials.
Cardiovascular diseases (CVDs) are the leading cause of death and disability worldwide. The CVDs are accompanied by inflammatory progression, resulting in innate and adaptive immune responses. Regulatory T cells (Tregs) have an immunosuppressive function and are one of the subsets of CD4 + T cells that play a crucial role in inflammatory diseases. Whether using Tregs as a biomarker for CVDs or targeting Tregs to exert cardioprotective functions by regulating immune balance, suppressing inflammation, suppressing cardiac and vascular remodeling, mediating immune tolerance, and promoting cardiac regeneration in the treatment of CVDs has become an emerging research focus. However, Tregs have plasticity, and this plastic Tregs lose immunosuppressive function and produce toxic effects on target organs in some diseases. This review aims to provide an overview of Tregs’ role and related mechanisms in CVDs, and reports on the research of plasticity Tregs in CVDs, to lay a foundation for further studies targeting Tregs in the prevention and treatment of CVDs.
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Wang et al. (2023) conducted a review in Cardiovascular diseases. Targeting regulatory T cells (Tregs) was evaluated. Targeting regulatory T cells has emerged as a potential therapeutic strategy for cardiovascular diseases by regulating immune balance, suppressing inflammation, and promoting cardiac regeneration.
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