Key result
Higher PRS strongly linked to elevated serum cardiac markers including NT-proBNP and ox-LDL.
Why the study?
Early CVD risk prediction is crucial, and discrete polygenic risk score measurement from at-home samples poses a convenient approach for early risk assessment.
Does a polygenic risk score correlate with serum biomarkers of cardiac health in individuals?
Population
184 individuals
Comparison
28 disease-associated SNPs and an aggregated PRS
Design
Cross-sectional association study
Authors
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May support PRS for biomarker risk assessment; leaves open prospective validation before clinical use.
Cross-Sectional (n=184)
Does a polygenic risk score correlate with serum biomarkers of cardiac health in individuals?
Effect estimate: r2 0.82 for NT-proBNP (95% CI 0.13-0.99)
p-value: p=.03
A polygenic risk score based on 28 SNPs significantly correlates with elevated levels of cardiac biomarkers like NT-proBNP and ox-LDL, suggesting its potential utility for early cardiovascular disease risk assessment.
Krishnamurthy et al. (2023) conducted a cross-sectional in Cardiovascular disease risk (n=184). Polygenic risk score (PRS) and disease-associated SNPs was evaluated on Association between PRS and serum cardiac markers (NT-proBNP and ox-LDL) (r2 0.82 for NT-proBNP, 95% CI 0.13-0.99, p=.03). A polygenic risk score was significantly correlated with increasing levels of serum cardiac markers, including NT-proBNP (r2=0.82; P=0.03) and ox-LDL (r2=0.94; P=0.005).
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