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BACKGROUND: T cells sensitises them to cellular death via antibody-dependent cellular cytotoxicity (ADCC) mediated by non-neutralising anti-cluster A antibodies (Abs) present in PLWH plasma. METHODS: T cells. FINDINGS: T cell counts. Anti-CD4BS antibodies blocked the coating of uninfected bystander cells by sgp120, thereby preventing their elimination by ADCC. Supporting a protective role of anti-CD4BS antibodies, their presence in PLWH plasma abrogated the negative association between CD4 counts and anti-cluster A Abs. INTERPRETATION: Our results reveal that anti-cluster A Abs are associated with immune dysfunction in PLWH and anti-CD4BS antibodies might have a beneficial impact in these individuals. FUNDING: This study was supported by the Canadian Institutes of Health Research, the Canada Foundation for Innovation, the Fonds de Recherche du Québec-Santé, and the National Institutes of Health.
Benlarbi et al. (Sat,) studied this question.
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