Why the study?
Does reperfusion-induced ventricular fibrillation alter transmembrane action potentials in subepicardial ventricular cells in an open-chest dog model?
Population
14 open-chest anesthetized dogs
Comparison
Reperfusion-induced ventricular fibrillation vs Prior to occlusion (control)
Design
Preclinical
Follow-up
first 10 min of reperfusion-induced VF
Authors
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Warrants caution against clinical extrapolation from canine VF models; leaves open whether slow-channel blockade modulates reperfusion arrhythmias in humans.
Does reperfusion-induced ventricular fibrillation alter transmembrane action potentials in subepicardial ventricular cells in an open-chest dog model?
Accurate action potential recording is possible from the in situ heart during VF, revealing that subepicardial cells in reperfused areas exhibit slow-channel type action potentials.
T. Akiyama (1981) studied this question.
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