Key result
Changes in central vascular hemodynamics were not significantly associated with cognitive functions during simulated work conditions with or without activity micro-breaks in young adult males.
Why the study?
Prolonged sitting is associated with compromised central vascular function, but the association between carotid vascular hemodynamic alterations and executive functions remained unexplored.
Does interrupting prolonged sitting with light or moderate intensity micro-breaks improve central vascular and cognitive functions in young adult males?
RCT (n=17)
Open-label
Computer randomization
No
Does interrupting prolonged sitting with light or moderate intensity micro-breaks improve central vascular and cognitive functions in young adult males?
Interrupting prolonged sitting with micro-breaks did not show a significant correlation between changes in carotid artery hemodynamics and executive functions in young adult males.
<ns3:p> <ns3:bold>Background:</ns3:bold> Alteration in the central vascular hemodynamics is speculated to influence cognitive functions, including executive functions in young adults. Prolonged sitting is associated with compromised central vascular functions, which activity micro-breaks could mitigate. However, the association between the carotid vascular hemodynamic alteration and the executive functions is yet to be explored. <ns3:bold>Methods:</ns3:bold> We administered a randomised controlled trial investigating the effects of various intensities' micro-breaks on central vascular and cognitive functions during simulated work conditions for four hours. The carotid artery hemodynamics and cognitive functions were measured by Duplex ultrasound at 0 <ns3:sup>th</ns3:sup> , 2 <ns3:sup>nd</ns3:sup> and 4 <ns3:sup>th</ns3:sup> hour and computer-based Flanker tests at 0 <ns3:sup>th</ns3:sup> , 1 <ns3:sup>st</ns3:sup> , 2 <ns3:sup>nd</ns3:sup> , 3 <ns3:sup>rd</ns3:sup> and 4 <ns3:sup>th</ns3:sup> hour of visit days, respectively. From the randomised controlled trial, we extracted the secondary data of carotid artery hemodynamics and cognitive functions change at the 4 <ns3:sup>th</ns3:sup> hour from the baseline and analysed for any relation. <ns3:bold>Results:</ns3:bold> Though we observed linear relation between the carotid artery hemodynamics and the executive functions, the relation was not statistically significant. we found a significant reduction in carotid artery diameter during prolonged sitting (0.03 cm [95%CI 0.01, 0.05]), velocity (10.35 cm/s [95%CI -2.85, 17.86]) and shear rate during interrupted sitting (174.39 [95%CI 65.67, 283.11]) We found increased accuracy during prolonged sitting (12.7% [95%CI 0.66, 24.81]) and sitting with light-intensity activity breaks (6.92% [95%CI 1.39, 12.44]). We did not find any significant relation between the change in central vascular functions (carotid artery diameter, velocity, shear rate and blood flow) and the cognitive functions during three different work conditions. <ns3:bold>Conclusion:</ns3:bold> Though a significant relation between carotid artery function and cognitive function could not be established, microbreaks can mitigate the vascular and cognitive risks associated with prolonged sitting. </ns3:p>
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P et al. (2022) conducted an RCT in Prolonged sitting (simulated work conditions) (n=17). Activity micro-breaks (walking or stair climbing) vs. Uninterrupted sitting was evaluated on Correlation between change in central vascular functions and cognitive functions at 4 hours. Changes in central vascular hemodynamics were not significantly associated with cognitive functions during simulated work conditions with or without activity micro-breaks in young adult males.
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