Key result
Women with ST-segment elevation acute myocardial infarction had significantly higher in-hospital mortality than men (6.6% vs 1.4%, p=0.003) and presented with less typical symptoms.
Why the study?
Do clinical features, symptoms, and in-hospital mortality differ between men and women presenting with ST-segment elevation acute myocardial infarction?
Observational (n=457)
No
Do clinical features, symptoms, and in-hospital mortality differ between men and women presenting with ST-segment elevation acute myocardial infarction?
Women presenting with ST-segment elevation myocardial infarction experience more atypical symptoms and higher in-hospital mortality compared to men, emphasizing the need for heightened clinical suspicion in female patients.
May warrant vigilance for atypical STEMI symptoms in women; leaves open whether targeted strategies narrow mortality gaps.
BACKGROUND: Many studies have examined sex-related differences in the clinical features of acute myocardial infarction (AMI). However, prospective studies are scant, and sex-related differences in symptoms of AMI remain unclear. We examined differences between men and women in terms of the clinical features of ST-segment elevation AMI. METHODS AND RESULTS: We studied 457 patients (106 women and 351 men) with ST-segment elevation AMI who were admitted within 24 h after symptom onset. The same cardiologist interviewed all patients within 48 h after admission. Women were older than men (72 vs 62 years, p<0.001) and had higher rates of hypertension (70 vs 56%, p=0.010), diabetes mellitus (36 vs 26%, p=0.047), and hyperlipidemia (51 vs 38%, p=0.019). Women were more likely than men to have non-specific symptoms (45 vs 34%, p=0.033), non-chest pain (pain in the jaw, throat, neck, shoulder, arm, hand, and back), mild pain (20 vs 7%, p<0.001), and nausea (49 vs 36%, p=0.013). On coronary angiography, the severity of coronary-artery lesions was similar in both sexes. In-hospital mortality was significantly higher in women than in men (6.6 vs 1.4%, p=0.003). CONCLUSIONS: Clinical profiles and presentations differ between women and men with AMI. Women have less typical symptoms of AMI than men.
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Kosuge et al. (2006) conducted an observational in ST-segment elevation acute myocardial infarction (n=457). Female sex vs. Male sex was evaluated on In-hospital mortality (p=0.003). Women with ST-segment elevation acute myocardial infarction had significantly higher in-hospital mortality than men (6.6% vs 1.4%, p=0.003) and presented with less typical symptoms.
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