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A three-dimensional electron density map has been calculated at 6 A resolution for a human γG1 immunoglobulin molecule. X-ray diffraction data have been collected for the native protein crystals and for three heavy atom derivatives prepared by soaking crystals in p-chloromercuribenzenesulfonate, Hg(CN)2, and PtCl6=. The electron density map is interpreted in terms of four possible models, of which a T-shaped model is favored. The dimensions of this model are compared with those reported by other physical and chemical techniques for immunoglobulin molecules.
Sarma et al. (Tue,) studied this question.